The use of pH to influence regio- and chemoselectivity in the asymmetric aminohydroxylation of styrenes.
نویسندگان
چکیده
[reaction: see text] The pH-controlled Sharpless asymmetric aminohydroxylation (AA) of styrenes provides 1-aryl-2-amino ethanols (regioisomer B) with high enantio-, chemo-, and regioselectivity. As existing AA protocols typically give regioisomer A as the major reaction product when using carbamate nitrogen sources, this method is a convenient alternative for the selective production of regioisomer B.
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ورودعنوان ژورنال:
- Organic letters
دوره 5 3 شماره
صفحات -
تاریخ انتشار 2003